The role of resistin and its relation to other pathogenetic factors of the chronic kidney disease development

Chronic kidney disease (CKD) is the leading cause of death from non-communicable diseases, and its prevalence in 2017 ranged 8.5 to 9.8%. Depending on stage CKD, 1 was diagnosed 3.5%, 2 3.2% 3 7.6%, while stages 4 5 took place 0.4 0.1% world’s population respectively. Obesity also contributes increase severity their combination occurs 3.1% patients. Kidney damage structural functional changes patients with obesity are associated high metabolic activity adipose tissue, due synthesis adipocytokines, including resistin. The purpose work : study resistin level blood early chronic disease, relation endothelin, markers lipid metabolism inflammation. Materials methods 70 88 CKD different were examined. Glomerular filtration rate (GFR) calculated by formula CKD-EPI based creatinine, cystatin C (CKD-EPIcysC / cr). levels C, resistin, tumor necrosis factor-alpha (TNF-α) endothelin-1 determined enzyme-linked immunosorbent assay. Determination total cholesterol low-density lipoprotein serum performed colorimetric method. Statistical analysis results help Statistica 6.0 statistical software package using Student’s t-test Spearman’s rank correlation coefficient. Results an 1.3 times 1.6 (p1.2 < 0.05), there a weak between concentration body mass index. A significant average negative GFR detected. Increased correlates increased TNF-α. In both groups, LDL increases simultaneously, them as progresses. Similar observed respect increasing concentrations endothelin-1. Thus, initiates number pathological changes, such systemic inflammation, hyperlipidemia endothelial dysfunction.